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PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation
Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα). PML-RARα is degraded by the proteasome by a SUMO-dependent, ubiquitin-mediated pathway in response to arsenic treatment,...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Company of Biologists
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3889398/ https://ncbi.nlm.nih.gov/pubmed/24190887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.132290 |
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