Herpes Simplex Virus 1 Ubiquitin Ligase ICP0 Interacts with PML Isoform I and Induces Its SUMO-Independent Degradation

Herpes simplex virus 1 (HSV-1) immediate-early protein ICP0 localizes to cellular structures known as promyelocytic leukemia protein (PML) nuclear bodies or ND10 and disrupts their integrity by inducing the degradation of PML. There are six PML isoforms with different C-terminal regions in ND10, of...

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Bibliographic Details
Main Authors: Cuchet-Lourenço, Delphine, Vanni, Emilia, Glass, Mandy, Orr, Anne, Everett, Roger D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457127/
https://ncbi.nlm.nih.gov/pubmed/22875967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01145-12
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