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Arsenic-Induced SUMO-Dependent Recruitment of RNF4 into PML Nuclear Bodies
In acute promyelocytic leukemia (APL), the promyelocytic leukemia (PML) protein is fused to the retinoic acid receptor alpha (RAR). Arsenic is an effective treatment for this disease as it induces SUMO-dependent ubiquitin-mediated proteasomal degradation of the PML-RAR fusion protein. Here we analyz...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Cell Biology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993750/ https://ncbi.nlm.nih.gov/pubmed/20943951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-05-0449 |
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