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Arsenic-Induced SUMO-Dependent Recruitment of RNF4 into PML Nuclear Bodies

In acute promyelocytic leukemia (APL), the promyelocytic leukemia (PML) protein is fused to the retinoic acid receptor alpha (RAR). Arsenic is an effective treatment for this disease as it induces SUMO-dependent ubiquitin-mediated proteasomal degradation of the PML-RAR fusion protein. Here we analyz...

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Detalles Bibliográficos
Main Authors: Geoffroy, Marie-Claude, Jaffray, Ellis G., Walker, Katherine J., Hay, Ronald T.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993750/
https://ncbi.nlm.nih.gov/pubmed/20943951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-05-0449
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