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The Auto-Generated Fragment of the Usp1 Deubiquitylase Is a Physiological Substrate of the N-End Rule Pathway

Deamidation of N-terminal Gln by the Ntaq1 Nt(Q)-amidase is a part of the Arg/N-end rule pathway, a ubiquitin-dependent proteolytic system. Here we identify Gln-Usp1(Ct), the C-terminal fragment of the autocleaved Usp1 deubiquitylase, as the first physiological Arg/N-end rule substrate that is targe...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Piatkov, Konstantin I., Colnaghi, Luca, Békés, Miklos, Varshavsky, Alexander, Huang, Tony T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889152/
https://ncbi.nlm.nih.gov/pubmed/23159736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.012
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