Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway

Substrates of a ubiquitin-dependent proteolytic system called the N-end rule pathway include proteins with destabilizing N-terminal residues. N-recognins, the pathway's ubiquitin ligases, contain three substrate-binding sites. The type-1 site is specific for basic N-terminal residues (Arg, Lys,...

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Main Authors: Xia, Zanxian, Webster, Ailsa, Du, Fangyong, Piatkov, Konstantin, Ghislain, Michel, Varshavsky, Alexander
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527112/
https://ncbi.nlm.nih.gov/pubmed/18566452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802583200
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