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Neurodegeneration-Associated Protein Fragments As Short-Lived Substrates of the N-End Rule Pathway

Protein aggregates are a common feature of neurodegenerative syndromes. Specific protein fragments were found previously to be aggregated in disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease. Here we show that the natural C-terminal fragments of Tau, TDP...

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Autors principals: Brower, Christopher S., Piatkov, Konstantin I., Varshavsky, Alexander
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640747/
https://ncbi.nlm.nih.gov/pubmed/23499006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.02.009
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