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Neurodegeneration-Associated Protein Fragments As Short-Lived Substrates of the N-End Rule Pathway

Protein aggregates are a common feature of neurodegenerative syndromes. Specific protein fragments were found previously to be aggregated in disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease. Here we show that the natural C-terminal fragments of Tau, TDP...

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書誌詳細
主要な著者: Brower, Christopher S., Piatkov, Konstantin I., Varshavsky, Alexander
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640747/
https://ncbi.nlm.nih.gov/pubmed/23499006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.02.009
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