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Neurodegeneration-Associated Protein Fragments As Short-Lived Substrates of the N-End Rule Pathway

Protein aggregates are a common feature of neurodegenerative syndromes. Specific protein fragments were found previously to be aggregated in disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease. Here we show that the natural C-terminal fragments of Tau, TDP...

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Detalhes bibliográficos
Main Authors: Brower, Christopher S., Piatkov, Konstantin I., Varshavsky, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640747/
https://ncbi.nlm.nih.gov/pubmed/23499006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.02.009
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