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Neurodegeneration-Associated Protein Fragments As Short-Lived Substrates of the N-End Rule Pathway

Protein aggregates are a common feature of neurodegenerative syndromes. Specific protein fragments were found previously to be aggregated in disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease. Here we show that the natural C-terminal fragments of Tau, TDP...

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Autores principales: Brower, Christopher S., Piatkov, Konstantin I., Varshavsky, Alexander
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640747/
https://ncbi.nlm.nih.gov/pubmed/23499006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.02.009
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