A bis-Benzylidine Piperidone Targeting Proteasome Ubiquitin Receptor RPN13/ADRM1 as a therapy for cancer

The bis-benzylidine piperidone RA190 covalently binds to cysteine 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function, triggering rapid accumulation of polyubiquitinated proteins. Multiple myeloma (MM) lines, even those resistant to bortezomib, were sensiti...

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Detalhes bibliográficos
Main Authors: Anchoori, Ravi K., Karanam, Balasubramanyam, Peng, Shiwen, Wang, Joshua W., Jiang, Rosie, Tanno, Toshihiko, Orlowski, Robert Z., Matsui, William, Zhao, Ming, Rudek, Michelle A., Hung, Chien-fu, Chen, Xiang, Walters, Kylie J., Roden, Richard B.S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3881268/
https://ncbi.nlm.nih.gov/pubmed/24332045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.11.001
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