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Lethal Mutagenesis Failure May Augment Viral Adaptation

Lethal mutagenesis, the attempt to extinguish a population by elevating its mutation rate, has been endorsed in the virology literature as a promising approach for treating viral infections. In support of the concept, in vitro studies have forced viral extinction with high doses of mutagenic drugs....

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Detalhes bibliográficos
Main Authors: Paff, Matthew L., Stolte, Steven P., Bull, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879444/
https://ncbi.nlm.nih.gov/pubmed/24092771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mst173
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