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Does Mutational Robustness Inhibit Extinction by Lethal Mutagenesis in Viral Populations?
Lethal mutagenesis is a promising new antiviral therapy that kills a virus by raising its mutation rate. One potential shortcoming of lethal mutagenesis is that viruses may resist the treatment by evolving genomes with increased robustness to mutations. Here, we investigate to what extent mutational...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2883602/ https://ncbi.nlm.nih.gov/pubmed/20548958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000811 |
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