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Empirical Complexities in the Genetic Foundations of Lethal Mutagenesis

From population genetics theory, elevating the mutation rate of a large population should progressively reduce average fitness. If the fitness decline is large enough, the population will go extinct in a process known as lethal mutagenesis. Lethal mutagenesis has been endorsed in the virology litera...

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Detalles Bibliográficos
Main Authors: Bull, James J., Joyce, Paul, Gladstone, Eric, Molineux, Ian J.
Formato: Artigo
Idioma:Inglês
Publicado: Genetics Society of America 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781979/
https://ncbi.nlm.nih.gov/pubmed/23934886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.154195
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