The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation

Ect2, a Rho guanine nucleotide exchange factor (RhoGEF), is atypical among RhoGEFs in its predominantly nuclear localization in interphase cells. One current model suggests that Ect2 mislocalization drives cellular transformation by promoting aberrant activation of cytoplasmic Rho family GTPase subs...

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Detalhes bibliográficos
Main Authors: Huff, Lauren P., DeCristo, Molly J., Trembath, Dimitri, Kuan, Pei Fen, Yim, Margaret, Liu, Jinsong, Cook, Danielle R., Miller, C. Ryan, Der, Channing J., Cox, Adrienne D.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877668/
https://ncbi.nlm.nih.gov/pubmed/24386507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601913514851
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