The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation

Ect2, a Rho guanine nucleotide exchange factor (RhoGEF), is atypical among RhoGEFs in its predominantly nuclear localization in interphase cells. One current model suggests that Ect2 mislocalization drives cellular transformation by promoting aberrant activation of cytoplasmic Rho family GTPase subs...

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Bibliografske podrobnosti
Main Authors: Huff, Lauren P., DeCristo, Molly J., Trembath, Dimitri, Kuan, Pei Fen, Yim, Margaret, Liu, Jinsong, Cook, Danielle R., Miller, C. Ryan, Der, Channing J., Cox, Adrienne D.
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2013
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877668/
https://ncbi.nlm.nih.gov/pubmed/24386507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601913514851
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