The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation

Ect2, a Rho guanine nucleotide exchange factor (RhoGEF), is atypical among RhoGEFs in its predominantly nuclear localization in interphase cells. One current model suggests that Ect2 mislocalization drives cellular transformation by promoting aberrant activation of cytoplasmic Rho family GTPase subs...

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Bibliografiset tiedot
Päätekijät: Huff, Lauren P., DeCristo, Molly J., Trembath, Dimitri, Kuan, Pei Fen, Yim, Margaret, Liu, Jinsong, Cook, Danielle R., Miller, C. Ryan, Der, Channing J., Cox, Adrienne D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: SAGE Publications 2013
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Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877668/
https://ncbi.nlm.nih.gov/pubmed/24386507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601913514851
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