Identification of Chimpanzee Fab Fragments by Repertoire Cloning and Production of a Full-Length Humanized Immunoglobulin G1 Antibody That Is Highly Efficient for Neutralization of Dengue Type 4 Virus

A safe and effective dengue vaccine is still not available. Passive immunization with monoclonal antibodies from humans or nonhuman primates represents an attractive alternative for the prevention of dengue virus infection. Fab monoclonal antibodies to dengue type 4 virus (DENV-4) were recovered by...

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Main Authors: Men, Ruhe, Yamashiro, Tetsu, Goncalvez, Ana P., Wernly, Claire, Schofield, Darren J., Emerson, Suzanne U., Purcell, Robert H., Lai, Ching-Juh
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC387713/
https://ncbi.nlm.nih.gov/pubmed/15078949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.9.4665-4674.2004
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