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Epitope Determinants of a Chimpanzee Dengue Virus Type 4 (DENV-4)-Neutralizing Antibody and Protection against DENV-4 Challenge in Mice and Rhesus Monkeys by Passively Transferred Humanized Antibody

The chimpanzee monoclonal antibody (MAb) 5H2 is specific for dengue virus type 4 (DENV-4) and neutralizes the virus at a high titer in vitro. The epitope detected by the antibody was mapped by sequencing neutralization escape variants of the virus. One variant contained a Lys(174)-Glu substitution a...

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Bibliografiske detaljer
Main Authors: Lai, Ching-Juh, Goncalvez, Ana P., Men, Ruhe, Wernly, Claire, Donau, Olivia, Engle, Ronald E., Purcell, Robert H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169078/
https://ncbi.nlm.nih.gov/pubmed/17881450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01420-07
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