Humanized Monoclonal Antibodies Derived from Chimpanzee Fabs Protect against Japanese Encephalitis Virus In Vitro and In Vivo

Japanese encephalitis virus (JEV)-specific Fab antibodies were recovered by repertoire cloning from chimpanzees initially immunized with inactivated JE-VAX and then boosted with attenuated JEV SA14-14-2. From a panel of 11 Fabs recovered by different panning strategies, three highly potent neutraliz...

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Detalhes bibliográficos
Main Authors: Goncalvez, Ana P., Chien, Cheng-Hsin, Tubthong, Kamolchanok, Gorshkova, Inna, Roll, Carrie, Donau, Olivia, Schuck, Peter, Yoksan, Sutee, Wang, Sy-Dar, Purcell, Robert H., Lai, Ching-Juh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446956/
https://ncbi.nlm.nih.gov/pubmed/18480437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00291-08
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