Novel Chimpanzee/Human Monoclonal Antibodies That Neutralize Anthrax Lethal Factor, and Evidence for Possible Synergy with Anti-Protective Antigen Antibody

Three chimpanzee Fabs reactive with lethal factor (LF) of anthrax toxin were isolated and converted into complete monoclonal antibodies (MAbs) with human γ1 heavy-chain constant regions. In a macrophage toxicity assay, two of the MAbs, LF10E and LF11H, neutralized lethal toxin (LT), a complex of LF...

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Autors principals: Chen, Zhaochun, Moayeri, Mahtab, Crown, Devorah, Emerson, Suzanne, Gorshkova, Inna, Schuck, Peter, Leppla, Stephen H., Purcell, Robert H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Microbial Immunity and Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738033/
https://ncbi.nlm.nih.gov/pubmed/19528217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00200-09
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