Efficient Neutralization of Anthrax Toxin by Chimpanzee Monoclonal Antibodies against Protective Antigen

Four single-chain variable fragments (scFvs) against protective antigen (PA) and 2 scFvs against lethal factor (LF) of anthrax were isolated from a phage display library generated from immunized chimpanzees. Only 2 scFvs recognizing PA (W1 and W2) neutralized the cytotoxicity of lethal toxin in a ma...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Chen, Zhaochun, Moayeri, Mahtab, Zhou, Yi-Hua, Leppla, Stephen, Emerson, Suzanne, Sebrell, Andrew, Yu, Fujuan, Svitel, Juraj, Schuck, Peter, St. Claire, Marisa, Purcell, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: The University of Chicago Press 2006
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Major Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7110013/
https://ncbi.nlm.nih.gov/pubmed/16453257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/500148
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