Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice

OBJECTIVE: W1-mAb is a chimpanzee-derived monoclonal antibody to protective antigen that improved survival when administered before anthrax lethal toxin challenge in rats. To better define W1-mAb’s efficacy for anthrax, we administered it after initiation of 24-hr infusions of edema toxin and lethal...

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Main Authors: Altaweel, Laith, Chen, Zhaochun, Moayeri, Mahtab, Cui, Xizhong, Li, Yan, Su, Junwu, Fitz, Yvonne, Johnson, Syd, Leppla, Stephen H., Purcell, Robert, Eichacker, Peter Q.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523297/
https://ncbi.nlm.nih.gov/pubmed/21336113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e3182120691
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