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Epitope Determinants of a Chimpanzee Fab Antibody That Efficiently Cross-Neutralizes Dengue Type 1 and Type 2 Viruses Map to Inside and in Close Proximity to Fusion Loop of the Dengue Type 2 Virus Envelope Glycoprotein

The epitope determinants of chimpanzee Fab antibody 1A5, which have been shown to be broadly reactive to flaviviruses and efficient for cross-neutralization of dengue virus type 1 and type 2 (DENV-1 and DENV-2), were studied by analysis of DENV-2 antigenic variants. Sequence analysis showed that one...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Goncalvez, Ana P., Purcell, Robert H., Lai, Ching-Juh
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2004
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525008/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15542644/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.23.12919-12928.2004
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