TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development

Induction of self-tolerance in developing T cells depends on medullary thymic epithelial cells (mTECs), whose development, in turn, requires signals from single-positive (SP) thymocytes. Thus, the absence of SP thymocytes in Tcra(−/−) mice results in a profound deficiency in mTECs. Here, we have pro...

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Autors principals: Jenkinson, S. Rhiannon, Williams, Joy A., Jeon, Hyein, Zhang, Jingjing, Nitta, Takeshi, Ohigashi, Izumi, Kruhlak, Michael, Zuklys, Saulius, Sharrow, Susan, Adams, Anthony, Granger, Larry, Choi, Yongwon, Siebenlist, Ulrich, Bishop, Gail A., Hollander, Georg A., Takahama, Yousuke, Hodes, Richard J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876204/
https://ncbi.nlm.nih.gov/pubmed/24324158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314859111
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