TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development

Induction of self-tolerance in developing T cells depends on medullary thymic epithelial cells (mTECs), whose development, in turn, requires signals from single-positive (SP) thymocytes. Thus, the absence of SP thymocytes in Tcra(−/−) mice results in a profound deficiency in mTECs. Here, we have pro...

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Detalhes bibliográficos
Main Authors: Jenkinson, S. Rhiannon, Williams, Joy A., Jeon, Hyein, Zhang, Jingjing, Nitta, Takeshi, Ohigashi, Izumi, Kruhlak, Michael, Zuklys, Saulius, Sharrow, Susan, Adams, Anthony, Granger, Larry, Choi, Yongwon, Siebenlist, Ulrich, Bishop, Gail A., Hollander, Georg A., Takahama, Yousuke, Hodes, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876204/
https://ncbi.nlm.nih.gov/pubmed/24324158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314859111
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