Thymic medullary epithelium and thymocyte self tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways

A critical process during thymic development of the T cell repertoire is the induction of self-tolerance. Tolerance in developing T cells is highly dependent on medullary thymic epithelial cells (mTEC) and mTEC development in turn requires signals from mature single positive (SP) thymocytes, a bidir...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Williams, Joy A., Zhang, Jingjing, Jeon, Hyein, Nitta, Takeshi, Ohigashi, Izumi, Klug, David, Kruhlak, Michael J., Choudhury, Baishakhi, Sharrow, Susan O., Granger, Larry, Adams, Anthony, Eckhaus, Michael A., Jenkinson, S. Rhiannon, Richie, Ellen R., Gress, Ronald E., Takahama, Yousuke, Hodes, Richard J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897934/
https://ncbi.nlm.nih.gov/pubmed/24337745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302550
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi