Thymic medullary epithelium and thymocyte self tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways

A critical process during thymic development of the T cell repertoire is the induction of self-tolerance. Tolerance in developing T cells is highly dependent on medullary thymic epithelial cells (mTEC) and mTEC development in turn requires signals from mature single positive (SP) thymocytes, a bidir...

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Main Authors: Williams, Joy A., Zhang, Jingjing, Jeon, Hyein, Nitta, Takeshi, Ohigashi, Izumi, Klug, David, Kruhlak, Michael J., Choudhury, Baishakhi, Sharrow, Susan O., Granger, Larry, Adams, Anthony, Eckhaus, Michael A., Jenkinson, S. Rhiannon, Richie, Ellen R., Gress, Ronald E., Takahama, Yousuke, Hodes, Richard J.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897934/
https://ncbi.nlm.nih.gov/pubmed/24337745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302550
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