CD86 Has Sustained Costimulatory Effects on CD8 T Cells

CD80 and CD86 both costimulate T cell activation. Their individual effects in vivo are difficult to study as they are coordinately up-regulated on APCs. We have studied mice expressing rat insulin promoter (RIP)-CD80 and RIP-CD86 on the NOD and NOD.scid genetic background to generate in vivo models,...

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Autori principali: Thomas, Ian J., de Marquesini, Liliana G. Petrich, Ravanan, Rommel, Smith, Richard M., Guerder, Sylvie, Flavell, Richard A., Wraith, David C., Wen, Li, Wong, F. Susan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629533/
https://ncbi.nlm.nih.gov/pubmed/17947667
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