Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins

When interacting with the CD4 receptor, the HIV gp120 envelope glycoprotein undergoes conformational changes that allow binding to the chemokine receptor. Receptor binding is proposed to lead to conformational changes in the gp41 transmembrane envelope glycoprotein involving the creation and/or expo...

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Bibliografiske detaljer
Main Authors: Si, Zhihai, Madani, Navid, Cox, Jason M., Chruma, Jason J., Klein, Jeffrey C., Schön, Arne, Phan, Ngoc, Wang, Liping, Biorn, Alyssa C., Cocklin, Simon, Chaiken, Irwin, Freire, Ernesto, Smith, Amos B., Sodroski, Joseph G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC387369/
https://ncbi.nlm.nih.gov/pubmed/15051887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307953101
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