Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins

When interacting with the CD4 receptor, the HIV gp120 envelope glycoprotein undergoes conformational changes that allow binding to the chemokine receptor. Receptor binding is proposed to lead to conformational changes in the gp41 transmembrane envelope glycoprotein involving the creation and/or expo...

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Detalhes bibliográficos
Main Authors: Si, Zhihai, Madani, Navid, Cox, Jason M., Chruma, Jason J., Klein, Jeffrey C., Schön, Arne, Phan, Ngoc, Wang, Liping, Biorn, Alyssa C., Cocklin, Simon, Chaiken, Irwin, Freire, Ernesto, Smith, Amos B., Sodroski, Joseph G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC387369/
https://ncbi.nlm.nih.gov/pubmed/15051887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307953101
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