Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins

When interacting with the CD4 receptor, the HIV gp120 envelope glycoprotein undergoes conformational changes that allow binding to the chemokine receptor. Receptor binding is proposed to lead to conformational changes in the gp41 transmembrane envelope glycoprotein involving the creation and/or expo...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Si, Zhihai, Madani, Navid, Cox, Jason M., Chruma, Jason J., Klein, Jeffrey C., Schön, Arne, Phan, Ngoc, Wang, Liping, Biorn, Alyssa C., Cocklin, Simon, Chaiken, Irwin, Freire, Ernesto, Smith, Amos B., Sodroski, Joseph G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC387369/
https://ncbi.nlm.nih.gov/pubmed/15051887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307953101
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi