Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins

When interacting with the CD4 receptor, the HIV gp120 envelope glycoprotein undergoes conformational changes that allow binding to the chemokine receptor. Receptor binding is proposed to lead to conformational changes in the gp41 transmembrane envelope glycoprotein involving the creation and/or expo...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Si, Zhihai, Madani, Navid, Cox, Jason M., Chruma, Jason J., Klein, Jeffrey C., Schön, Arne, Phan, Ngoc, Wang, Liping, Biorn, Alyssa C., Cocklin, Simon, Chaiken, Irwin, Freire, Ernesto, Smith, Amos B., Sodroski, Joseph G.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 2004
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387369/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15051887/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307953101
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