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Systemic resistance to methotrexate in transgenic mice carrying a mutant dihydrofolate reductase gene.
A full-length cDNA coding for a mutant dihydrofolate reductase (DHFR; 5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase, EC 1.5.1.3), cloned from a mouse fibroblast cell line grown in high concentrations of methotrexate (MTX), was microinjected into mouse embryos to produce transgenic mice. The DHFR cD...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1986
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC387192/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3467329/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.24.9621 |
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