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Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

Steady-state dihydrofolate reductase (dhfr) mRNA levels were decreased as a result of nonsense mutations in the dhfr gene. Thirteen DHFR-deficient mutants were isolated after treatment of Chinese hamster ovary cells with UV irradiation. The positions of most point mutations were localized by RNA het...

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Bibliografski detalji
Glavni autori: Urlaub, G, Mitchell, P J, Ciudad, C J, Chasin, L A
Format: Artigo
Jezik:Inglês
Izdano: 1989
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC362753/
https://ncbi.nlm.nih.gov/pubmed/2779551
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