Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

Steady-state dihydrofolate reductase (dhfr) mRNA levels were decreased as a result of nonsense mutations in the dhfr gene. Thirteen DHFR-deficient mutants were isolated after treatment of Chinese hamster ovary cells with UV irradiation. The positions of most point mutations were localized by RNA het...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Urlaub, G, Mitchell, P J, Ciudad, C J, Chasin, L A
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1989
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362753/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2779551/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.7.2868-2880.1989
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