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p16(INK4a) reporter mice reveal age-promoting effects of environmental toxicants
While murine-based systems to identify cancer-promoting agents (carcinogens) are established, models to identify compounds that promote aging (gerontogens) have not been described. For this purpose, we exploited the transcription of p16(INK4a), which rises dynamically with aging and correlates with...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3871242/ https://ncbi.nlm.nih.gov/pubmed/24334456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70960 |
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