Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy

Orexin neuropeptides influence multiple homeostatic functions and play an essential role in the expression of normal sleep-wake behavior. While their two known receptors (OX(1) and OX(2)) are targets for novel pharmacotherapeutics, the actions mediated by each receptor remain largely unexplored. Usi...

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Hlavní autoři: Kohlmeier, Kristi A., Tyler, Christopher J., Kalogiannis, Mike, Ishibashi, Masaru, Kristensen, Morten P., Gumenchuk, Iryna, Chemelli, Richard M., Kisanuki, Yaz Y., Yanagisawa, Masashi, Leonard, Christopher S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2013
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869224/
https://ncbi.nlm.nih.gov/pubmed/24391530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2013.00246
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