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Nitric Oxide and Interleukin-1β Stimulate the Proteasome-Independent Degradation of the Retinoic Acid Hydroxylase CYP2C22 in Primary Rat Hepatocytes

CYP2C22 was recently described as a retinoic acid–metabolizing cytochrome P450 enzyme whose transcription is induced by all-trans-retinoic acid (atRA) in hepatoma cells (Qian L, Zolfaghari R, and Ross AC (2010) J Lipid Res 51:1781–1792). We identified CYP2C22 as a putative nitric oxide (NO)–regulate...

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Библиографические подробности
Главные авторы: Lee, Choon-myung, Lee, Bang-sub, Arnold, Samuel L., Isoherranen, Nina, Morgan, Edward T.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868880/
https://ncbi.nlm.nih.gov/pubmed/24144795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.209841
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