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Cofactor Molecules Induce Structural Transformation During Infectious Prion Formation

The spread of misfolded proteins has been implicated in a wide variety of neurodegenerative diseases. Prions associated with spongiform encephalopathy are currently the only misfolded proteins in which high specific biological infectivity can be produced in vitro. Using a system that generates infec...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Miller, Michael B., Wang, Daphne W., Wang, Fei, Noble, Geoffrey P., Ma, Jiyan, Woods, Virgil L., Li, Sheng, Supattapone, Surachai
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863764/
https://ncbi.nlm.nih.gov/pubmed/24120764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.08.025
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