Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions

Prions containing misfolded prion protein (PrP(Sc)) can be formed with cofactor molecules using the technique of serial protein misfolding cyclic amplification. However, it remains unknown whether cofactors materially participate in maintaining prion conformation and infectious properties. Here we s...

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Bibliographic Details
Main Authors: Deleault, Nathan R., Walsh, Daniel J., Piro, Justin R., Wang, Fei, Wang, Xinhe, Ma, Jiyan, Rees, Judy R., Supattapone, Surachai
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396481/
https://ncbi.nlm.nih.gov/pubmed/22711839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206999109
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