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Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions
Prions containing misfolded prion protein (PrP(Sc)) can be formed with cofactor molecules using the technique of serial protein misfolding cyclic amplification. However, it remains unknown whether cofactors materially participate in maintaining prion conformation and infectious properties. Here we s...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3396481/ https://ncbi.nlm.nih.gov/pubmed/22711839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206999109 |
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