Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions

Prions containing misfolded prion protein (PrP(Sc)) can be formed with cofactor molecules using the technique of serial protein misfolding cyclic amplification. However, it remains unknown whether cofactors materially participate in maintaining prion conformation and infectious properties. Here we s...

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Autori principali: Deleault, Nathan R., Walsh, Daniel J., Piro, Justin R., Wang, Fei, Wang, Xinhe, Ma, Jiyan, Rees, Judy R., Supattapone, Surachai
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396481/
https://ncbi.nlm.nih.gov/pubmed/22711839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206999109
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