Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions

Prions containing misfolded prion protein (PrP(Sc)) can be formed with cofactor molecules using the technique of serial protein misfolding cyclic amplification. However, it remains unknown whether cofactors materially participate in maintaining prion conformation and infectious properties. Here we s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Deleault, Nathan R., Walsh, Daniel J., Piro, Justin R., Wang, Fei, Wang, Xinhe, Ma, Jiyan, Rees, Judy R., Supattapone, Surachai
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396481/
https://ncbi.nlm.nih.gov/pubmed/22711839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206999109
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