Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions

Prions containing misfolded prion protein (PrP(Sc)) can be formed with cofactor molecules using the technique of serial protein misfolding cyclic amplification. However, it remains unknown whether cofactors materially participate in maintaining prion conformation and infectious properties. Here we s...

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Detalhes bibliográficos
Main Authors: Deleault, Nathan R., Walsh, Daniel J., Piro, Justin R., Wang, Fei, Wang, Xinhe, Ma, Jiyan, Rees, Judy R., Supattapone, Surachai
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396481/
https://ncbi.nlm.nih.gov/pubmed/22711839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206999109
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