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Computational Design of an Unnatural Amino Acid Dependent Metalloprotein with Atomic Level Accuracy

Genetically encoded unnatural amino acids could facilitate the design of proteins and enzymes of novel function, but correctly specifying sites of incorporation, and the identities and orientations of surrounding residues represents a formidable challenge. Computational design methods have been used...

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Autors principals: Mills, Jeremy H., Khare, Sagar D., Bolduc, Jill M., Forouhar, Farhad, Mulligan, Vikram Khipple, Lew, Scott, Seetharaman, Jayaraman, Tong, Liang, Stoddard, Barry L., Baker, David
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863684/
https://ncbi.nlm.nih.gov/pubmed/23924187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja403503m
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