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Computational Design of an Unnatural Amino Acid Dependent Metalloprotein with Atomic Level Accuracy

Genetically encoded unnatural amino acids could facilitate the design of proteins and enzymes of novel function, but correctly specifying sites of incorporation, and the identities and orientations of surrounding residues represents a formidable challenge. Computational design methods have been used...

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Detalhes bibliográficos
Main Authors: Mills, Jeremy H., Khare, Sagar D., Bolduc, Jill M., Forouhar, Farhad, Mulligan, Vikram Khipple, Lew, Scott, Seetharaman, Jayaraman, Tong, Liang, Stoddard, Barry L., Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863684/
https://ncbi.nlm.nih.gov/pubmed/23924187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja403503m
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