Design of activated serine-containing catalytic triads with atomic level accuracy

A challenge in the computational design of enzymes is that multiple properties must be simultaneously optimized -- substrate-binding, transition state stabilization, and product release -- and this has limited the absolute activity of successful designs. Here, we focus on a single critical property...

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Hlavní autoři: Rajagopalan, Sridharan, Wang, Chu, Yu, Kai, Kuzin, Alexandre P., Richter, Florian, Lew, Scott, Miklos, Aleksandr E., Matthews, Megan L., Seetharaman, Jayaraman, Su, Min, Hunt, John. F., Cravatt, Benjamin F., Baker, David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048123/
https://ncbi.nlm.nih.gov/pubmed/24705591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1498
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