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Design of activated serine-containing catalytic triads with atomic level accuracy
A challenge in the computational design of enzymes is that multiple properties must be simultaneously optimized -- substrate-binding, transition state stabilization, and product release -- and this has limited the absolute activity of successful designs. Here, we focus on a single critical property...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2014
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4048123/ https://ncbi.nlm.nih.gov/pubmed/24705591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1498 |
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