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The role of imidazole in peptide cyclization by transesterification: parallels to the catalytic triads of serine proteases
The improved bioavailability, stability and selectivity of cyclic peptides over their linear counterparts make them attractive structures in the design and discovery of novel therapeutics. In our previous work, we developed an imidazole-promoted preparation of cyclic depsipeptides in which we observ...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4106122/ https://ncbi.nlm.nih.gov/pubmed/23529282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob27464k |
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