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Synthesis of Cyclic Peptides through Direct Aminolysis of Peptide Thioesters Catalyzed by Imidazole in Aqueous Organic Solutions

A promising method for the synthesis of cyclic peptides through the direct aminolysis of peptide thioesters is presented. The cyclization step was carried out in a mixture of acetonitrile and 1.5 M aqueous imidazole solution with no observable oligomers. Studies on the N- and C-terminal residues sho...

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מידע ביבליוגרפי
Main Authors: Li, Yangmei, Yongye, Austin, Giulianotti, Marc, Martinez-Mayorga, Karina, Yu, Yongping, Houghten, Richard A.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121167/
https://ncbi.nlm.nih.gov/pubmed/19894764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc900100z
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