Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation

Despite evidence for the impact of insulin on intestinal epithelial physiology and pathophysiology, the expression patterns, roles, and regulation of insulin receptor (IR) and IR isoforms in the intestinal epithelium are not well characterized. IR-A is thought to mediate the proliferative effects of...

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Bibliografiska uppgifter
Huvudupphovsmän: Andres, Sarah F., Simmons, James G., Mah, Amanda T., Santoro, M. Agostina, Van Landeghem, Laurianne, Lund, P. Kay
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Company of Biologists 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3860310/
https://ncbi.nlm.nih.gov/pubmed/24127567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.132985
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