Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells

Intestinal epithelial stem cells (IESCs) are critical to maintain intestinal epithelial function and homeostasis. We tested the hypothesis that aging promotes IESC dysfunction using old (18-22 months) and young (2-4 month) Sox9-EGFP IESC reporter mice. Different levels of Sox9-EGFP permit analyses o...

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Détails bibliographiques
Publié dans:Aging (Albany NY)
Auteurs principaux: Moorefield, Emily C., Andres, Sarah F., Blue, R. Eric, Van Landeghem, Laurianne, Mah, Amanda T., Santoro, M. Agostina, Ding, Shengli
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5611984/
https://ncbi.nlm.nih.gov/pubmed/28854151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101279
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