IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations

Insulin-like growth factor 1 (IGF1) has potent trophic effects on normal or injured intestinal epithelium, but specific effects on intestinal stem cells (ISCs) are undefined. We used Sox9-enhanced green fluorescent protein (EGFP) reporter mice that permit analyses of both actively cycling ISCs (Sox9...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Van Landeghem, Laurianne, Santoro, M. Agostina, Mah, Amanda T., Krebs, Adrienne E., Dehmer, Jeffrey J., McNaughton, Kirk K., Helmrath, Michael A., Magness, Scott T., Lund, P. Kay
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478798/
https://ncbi.nlm.nih.gov/pubmed/25837582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-264010
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