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Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner()
Inefficient thymic negative selection of self-specific T cells is associated with several autoimmune diseases, including type 1 diabetes (T1D). The factors that influence the efficacy of thymic negative selection, and the kinetics of thymic output of autoreactive T cells remain ill-defined. We inves...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3858497/ https://ncbi.nlm.nih.gov/pubmed/24198282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302273 |
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