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Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner()

Inefficient thymic negative selection of self-specific T cells is associated with several autoimmune diseases, including type 1 diabetes (T1D). The factors that influence the efficacy of thymic negative selection, and the kinetics of thymic output of autoreactive T cells remain ill-defined. We inves...

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Autori principali: He, Qiuming, Morillon, Y. Maurice, Spidale, Nicholas A., Kroger, Charles J., Liu, Bo, Sartor, R. Balfour, Wang, Bo, Tisch, Roland
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858497/
https://ncbi.nlm.nih.gov/pubmed/24198282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302273
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