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Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis

Mucosal surfaces of the lower gastrointestinal tract are subject to frequent, pronounced fluctuations in oxygen tension, particularly during inflammation. Adaptive responses to hypoxia are orchestrated largely by the hypoxia-inducible transcription factors (HIFs). As HIF-1α and HIF-2α are coexpresse...

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Библиографические подробности
Главные авторы: Glover, Louise E., Bowers, Brittelle E., Saeedi, Bejan, Ehrentraut, Stefan F., Campbell, Eric L., Bayless, Amanda J., Dobrinskikh, Evgenia, Kendrick, Agnieszka A., Kelly, Caleb J., Burgess, Adrianne, Miller, Lauren, Kominsky, Douglas J., Jedlicka, Paul, Colgan, Sean P.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856803/
https://ncbi.nlm.nih.gov/pubmed/24248342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302840110
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