HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity

Intestinal epithelial cells (IECs) are exposed to profound fluctuations in oxygen tension and have evolved adaptive transcriptional responses to a low-oxygen environment. These adaptations are mediated primarily through the hypoxia-inducible factor (HIF) complex. Given the central role of the IEC in...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Saeedi, Bejan J., Kao, Daniel J., Kitzenberg, David A., Dobrinskikh, Evgenia, Schwisow, Kayla D., Masterson, Joanne C., Kendrick, Agnieszka A., Kelly, Caleb J., Bayless, Amanda J., Kominsky, Douglas J., Campbell, Eric L., Kuhn, Kristine A., Furuta, Glenn T., Colgan, Sean P., Glover, Louise E.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2015
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462943/
https://ncbi.nlm.nih.gov/pubmed/25904334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-07-1194
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