Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis

Epithelial barrier dysfunction is a significant factor in many allergic diseases, including eosinophilic esophagitis (EoE). Infiltrating leukocytes and tissue adaptations increase metabolic demands and decrease oxygen availability at barrier surfaces. Understanding of how these processes impact barr...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Masterson, Joanne C., Biette, Kathryn A., Hammer, Juliet A., Nguyen, Nathalie, Capocelli, Kelley E., Saeedi, Bejan J., Harris, Rachel F., Fernando, Shahan D., Hosford, Lindsay B., Kelly, Caleb J., Campbell, Eric L., Ehrentraut, Stefan F., Ahmed, Faria N., Nakagawa, Hiroshi, Lee, James J., McNamee, Eóin N., Glover, Louise E., Colgan, Sean P., Furuta, Glenn T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668670/
https://ncbi.nlm.nih.gov/pubmed/31264974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126744
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